Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-acetamino-3-methyl-N-(beta-methanesulfonamidoethyl)-N-ethylaniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | N-(2-Chloroethyl)methanesulphonamide | HCID 89092 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 4-Acetamino-3-methyl-N-ethylaniline | HCID 21452831 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-acetamino-3-methyl-N-(beta-methanesulfonamidoethyl)-N-ethylaniline | HCID 21452834 | — |
반응 단계
A mixture of 57.6g of 4-acetamino-3-methyl-N-ethylaniline, 52g of βmethanesulfonamidoethyl chloride, 27.7g of sodium hydrogen carbonate, 70g of water and 70ml of methanol were refluxed for 5 hours, and thereafter the methanol was distilled out under reduced pressure. Water was added to the reaction system and an oily product separated out. This oily product was poured into ethyl acetate and cooled to obtain white 4-acetamino-3-methyl-N-(β-methanesulfonamidoethyl)-N-ethylaniline.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04009205 |
| 출처 데이터셋 | uspto-grants-1977_02 |
| ORD ID | ord-0415ffa5af224365b1f5a0fffd76f923 |
| 출처 메모 | uspto-grants-1977_02 |