Water → 2-Amino-5-(diethylamino)toluene

HRID 436552

반응식

HRID 436552 반응식
[NH:1]([C:5]1[CH:15]=[CH:14][C:8]([N:9]([CH2:12][CH3:13])[CH2:10][CH3:11])=[CH:7][C:6]=1[CH3:16])C(C)=O.O.[OH-].[Na+]>S(=O)(=O)(O)O>[NH2:1][C:5]1[CH:15]=[CH:14][C:8]([N:9]([CH2:10][CH3:11])[CH2:12][CH3:13])=[CH:7][C:6]=1[CH3:16]

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 222177N-[4-(diethylamino)-2-methylphenyl]acetamide

생성물 1

HCID 673642-Amino-5-(diethylamino)toluene

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

22g of 4-acetamino-3-methyl-(N,N-diethyl)aniline were dissolved in 30g of 50% sulfuric acid and stirred and reacted for 5 hours at 80° to 100° C. Then, after 50g of water had been added thereto, the reaction mixture was neutralized with 30% sodium hydroxide and extracted with 150ml of benzole. The benzole used was distilled off from the extract to obtain 14.4g of 4-amino-3-methyl-(N,N-diethyl)aniline. The product was distilled for purification under a reduced pressure of 130° C/2mmHg to obtain 13.5g of 4-amino-3-methyl-(N,N-diethyl) aniline. The free amine was dissolved in 100ml of diethyl ether and was converted to the hydrogen chloride salt thereof by introducing dry hydrogen chloride gas into the system. Then, the salt was filtered out and dried to obtain 17.7g of 4-amino-3-metnyl-(N,N-diethyl)aniline hydrochloride.

후처리

  1. customreacted for 5 hours at 80° to 100° C
  2. extractionextracted with 150ml of benzole
  3. distillationThe benzole used was distilled off from the
  4. extractionextract

출처 및 근거

ORD 기록
ord-0121c25b959b420c9d20d0d33ae2a37a
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04009205

연결된 노트

불러오는 중…