C1([O:4]C2C=CC(C(O)=O)=CC=2)CC1.C(C1C=C(O)C=CC=1C(N)=O)C.C1(Br)CCC1.C(=O)([O-])[O-].[K+:35].[K+].[I-].[K+].[CH:39]1([O:43][C:44]2[CH:54]=[CH:53][C:47]([C:48]([O:50]CC)=[O:49])=[CH:46][CH:45]=2)[CH2:42][CH2:41][CH2:40]1>CN(C)C=O>[CH:39]1([O:43][C:44]2[CH:54]=[CH:53][C:47]([C:48]([OH:50])=[O:49])=[CH:46][CH:45]=2)[CH2:42][CH2:41][CH2:40]1.[OH-:4].[K+:35]The intermediate 4-cyclobutyloxybenzoic acid was prepared following the procedure described in Example 108 for the preparation of the corresponding 4 -cyclopropyloxybenzoic acid using 25 g. of ethyl 4-hydroxybenzamide, 23.1 g. of cyclobutyl bromide, 31 g. of anhydrous potassium carbonate, 2.5 g. of potassium iodide and 300 ml. of dimethylformamide to yield 20.1 g. of ethyl 4-cyclobutyloxybenzoate, which was then hydrolyzed by heating with 200 ml. of 10% aqueous potassium hydroxide solution as in Example 108 to yield 12.7 g. of 4-cyclobutyloxybenzoic acid, m.p. 192°-195° C. after recrystallization from 400 ml. of acetonitrile.
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