Ammonia → 3-Thiophenecarboxylic acid, 4-(aminosulfonyl)-, methyl ester

HRID 436828노트

반응식

HRID 436828 반응식
Cl[S:2]([C:5]1[C:6]([C:10]([O:12][CH3:13])=[O:11])=[CH:7][S:8][CH:9]=1)(=[O:4])=[O:3].[NH3:14]>C(Cl)(Cl)Cl>[S:2]([C:5]1[C:6]([C:10]([O:12][CH3:13])=[O:11])=[CH:7][S:8][CH:9]=1)(=[O:4])(=[O:3])[NH2:14]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 12593671Methyl 4-(chlorosulfonyl)thiophene-3-carboxylate

생성물 1

HCID 30422843-Thiophenecarboxylic acid, 4-(aminosulfonyl)-, methyl ester

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

39.9 g (0.166 mole) of methyl 4-chlorosulfonylthiophene-3-carboxylate (VIII) is dissolved in 400 ml of absolute chloroform; ammonia is passed in at room temperature until the mixture has an alkaline reaction. After the mixture has been stirred for a further 3 hours (care being taken that the solution remains alkaline) it is extracted with water and the organic phase is dried and evaporated. The crystalline residue can be recrystallized from ethanol; however, for further use, digestion with ether is sufficient.

후처리

  1. customis passed in at room temperature until the mixture
  2. customan alkaline reaction
  3. extractionis extracted with water
  4. customthe organic phase is dried
  5. customevaporated
  6. customThe crystalline residue can be recrystallized from ethanol

출처 및 근거

ORD 기록
ord-ea5cf465562c4a609d34e2c35fc2658b
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04028373

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