Ammonia → Methyl 3-(aminosulfonyl)-2-thiophenecarboxylate

HRID 436831

반응식

HRID 436831 반응식
Cl[S:2]([C:5]1[CH:9]=[CH:8][S:7][C:6]=1[C:10]([O:12][CH3:13])=[O:11])(=[O:4])=[O:3].[NH3:14]>C(Cl)(Cl)Cl>[S:2]([C:5]1[CH:9]=[CH:8][S:7][C:6]=1[C:10]([O:12][CH3:13])=[O:11])(=[O:4])(=[O:3])[NH2:14]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 27367332-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-, methyl ester

생성물 1

HCID 101012Methyl 3-(aminosulfonyl)-2-thiophenecarboxylate

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

43.5 g (0.181 mole) of methyl 3-chlorosulfonylthiophene-2-carboxylate (VIII) is dissolved in 450 ml of absolute chloroform; ammonia is passed in at room temperature until the mixture has an alkaline reaction. After stirring the solution for a further 3 hours at room temperature (care being taken to keep the solution alkaline) it is extracted with water and the organic phase is dried and evaporated. The crystalline residue may be recrystallized from ethanol; however, for further reaction digestion with ether is sufficient.

후처리

  1. customis passed in at room temperature until the mixture
  2. customan alkaline reaction
  3. extractionis extracted with water
  4. customthe organic phase is dried
  5. customevaporated
  6. customThe crystalline residue may be recrystallized from ethanol

출처 및 근거

ORD 기록
ord-51332c6b1b534fad9c929433efb4889c
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04028373

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