Hydrochloric Acid → 10-Methoxy-6,10-dimethyl-5-undecene-2-one

HRID 436878노트

반응식

HRID 436878 반응식
C1CO[C:3]([CH2:5][CH2:6][CH:7]=[C:8]([CH3:17])[CH2:9][CH2:10][CH2:11][C:12]([O:15][CH3:16])([CH3:14])[CH3:13])([CH3:4])[O:2]1.Cl>CO.O>[CH3:16][O:15][C:12]([CH3:14])([CH3:13])[CH2:11][CH2:10][CH2:9][C:8]([CH3:17])=[CH:7][CH2:6][CH2:5][C:3](=[O:2])[CH3:4]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 77886384HCID 77886384, 화합물

생성물 1

HCID 5396652510-Methoxy-6,10-dimethyl-5-undecene-2-one수율 97.7%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

This and the next reaction could be effected with the E and Z isomers or mixtures thereof. A solution of 1.1 g of 2,2-ethylenedioxy-10-methoxy-6,10-dimethyl-5-undecene in 22 ml of methanol containing 11 ml of 0.5N aqueous hydrochloric acid was stirred for 20 hours at room temperature and was then diluted with water and extracted with petroleum ether (b.p.= 40°-75° C.). The extracts were washed with an aqueous sodium bicarbonate solution, then with water and evaporated to dryness to obtain 900 mg of 10-methoxy-6,10-dimethyl-5-undecene-2-one in the form of a colorless oil which was used as is for the next step.

후처리

  1. customThis and the next reaction
  2. extractionextracted with petroleum ether (b.p.= 40°-75° C.)
  3. washThe extracts were washed with an aqueous sodium bicarbonate solution
  4. customwith water and evaporated to dryness

출처 및 근거

ORD 기록
ord-ffc1eb2e07c54bd5b522fd7ebf07e5e6
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04028386

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