Water → Cyclobutyl(4-methylphenyl)methanone

HRID 436926노트

반응식

HRID 436926 반응식
[CH:1]1([C:5](Cl)=[O:6])[CH2:4][CH2:3][CH2:2]1.[Cl-].[Al+3].[Cl-].[Cl-].O.[C:13]1([CH3:19])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:13]1([CH3:19])[CH:18]=[CH:17][C:16]([C:5]([CH:1]2[CH2:4][CH2:3][CH2:2]2)=[O:6])=[CH:15][CH:14]=1

참가 물질

5

반응물 4

HCID 962WaterHCID 1140Toluene2회HCID 78705Cyclobutanecarbonyl chlorideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 316820Cyclobutyl(4-methylphenyl)methanone

실험 절차

Cyclobutylcarbonyl chloride (23.8 g.) in dry toluene (25 ml) was added dropwise during 1 hour to a stirred suspension of anhydrous aluminium chloride (29.4 g) in dry toluene (150 ml). After stirring a further 20 minutes, the mixture was poured into iced water (1 l) and the organic layer was separated, washed with water, dried over magnesium sulphate, filtered and evaporated. The residue was distilled under reduced pressure and the fraction b.p. 79-80°/0.03 mm was collected. On standing the product solidified and the solid had m.p. 32°-34°.

후처리

  1. customthe organic layer was separated
  2. washwashed with water
  3. dry with materialdried over magnesium sulphate
  4. filtrationfiltered
  5. customevaporated
  6. distillationThe residue was distilled under reduced pressure
  7. customthe fraction b.p. 79-80°/0.03 mm was collected

출처 및 근거

ORD 기록
ord-6f813a29c7da4115a3f02b2b9428c00e
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04028404

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