Hydrochloric Acid → HCID 70633642, 화합물

HRID 436952노트

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HRID 436952 반응식
[Cl:1]C1C=C(Cl)C(Cl)=CC=1OC(=O)[C@H](CC1C=CC=CC=1)NC(OC(C)(C)C)=O.C(OC(=O)[C@H](CCSC)N)C1C=CC=CC=1.[CH2:45]([O:52][C:53](=[O:78])[C@H:54]([CH2:74][CH2:75][S:76][CH3:77])[NH:55][C:56](=[O:73])[C@H:57]([CH2:66][C:67]1[CH:72]=[CH:71][CH:70]=[CH:69][CH:68]=1)[NH:58]C(OC(C)(C)C)=O)[C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1.Cl>O1CCOCC1.C(Cl)Cl>[ClH:1].[CH2:45]([O:52][C:53](=[O:78])[C@H:54]([CH2:74][CH2:75][S:76][CH3:77])[NH:55][C:56](=[O:73])[C@H:57]([CH2:66][C:67]1[CH:68]=[CH:69][CH:70]=[CH:71][CH:72]=1)[NH2:58])[C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 11673142HCID 11673142, 화합물HCID 13306570N-t-butoxycarbonyl-L-phenylalanine 2,4,5-trichlorophenyl esterHCID 53827275HCID 53827275, 화합물

생성물 1

HCID 70633642HCID 70633642, 화합물

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 312751,4-Dioxane용매2회

실험 절차

A solution of 21.2 parts N-t-butoxycarbonyl-L-phenylalanine 2,4,5-trichlorophenyl ester and 12.7 parts L-methionine benzyl ester in 200 parts methylene chloride is stirred overnight at room temperature. Completion of the reaction is determined by thin layer chromatography. The solvent is then stripped under reduced pressure and the crude residue subjected to low pressure column chromatography on silica gel. The resulting product, N-t-butoxycarbonyl-L-phenylalanyl-L-methionine benzyl ester, is dissolved in 50 parts dioxane and stirred with a 10 fold excess of 2 N HCl in dioxane for 10 minutes. The solvent is removed by evaporation under reduced pressure. The solid residue, after trituration with ethyl ether, affords pure L-phenylalanyl-L-methionine benzyl ester hydrochloride. This compound is represented by the following formula

후처리

  1. customThe solvent is removed by evaporation under reduced pressure

출처 및 근거

ORD 기록
ord-13666bc650ac4756b6681b33277d8db6
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04028319

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