Ubenimex → L-Leucine

HRID 437009

반응식

HRID 437009 반응식
[CH3:1][CH:2]([CH2:4][C@H:5]([NH:9]C([C@@H](O)[C@H](N)CC1C=CC=CC=1)=O)[C:6]([OH:8])=[O:7])[CH3:3]>Cl>[NH2:9][C@H:5]([C:6]([OH:8])=[O:7])[CH2:4][CH:2]([CH3:3])[CH3:1]

참가 물질

3

반응물 1

HCID 72172Ubenimex

생성물 1

HCID 6106L-Leucine

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

The hydrolysis of bestatin in 6N HCl at 100° C. for 18 hours yields L-leucine and an unusual amino acid. The ratio of these amino acids is 1:1. Bestatin gives positive Rydon-Smith and ninhydrin reactions. The amino acid sequence of bestatin shown in the structure was elucidated by fragmentation pattern in mass spectrum of bestatin methyl ester hydrochloride. Thus, the structure of bestatin is (2S,3R)-3-amino-2-hydroxy-4-phenylbutyryl-L-leucine.

출처 및 근거

ORD 기록
ord-4b35802d46464e9cb7248cada345d15e
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04029547

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