참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | DI-Sec-butylamine | HCID 12277 | — |
| 반응물 | 2-Chloro-1-{1-[(2-fluorophenyl)methyl]-1H-pyrrol-2-yl}ethan-1-one | HCID 20391531 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | 1-(o-Fluorobenzyl)-2[(di-sec-butylamino)acetyl]pyrrole | HCID 20391558 | — |
반응 단계
A mixture of 16.0 g of 2-chloroacetyl-1-(o-fluorobenzyl)pyrrole, Example 1a, 8.3 g of di-sec-butylamine and 20.0 g of potassium carbonate in 250 ml xylene is stirred at 120° C. for 72 hours. The mixture is cooled, washed with water, dried and filtered and the xylene is evaporated leaving a brown oil. The oil is dissolved in ether and extracted into a 2N hydrogen chloride solution. The aqueous acidic solution is basified with a sodium carbonate solution and extracted with ether. The ether solution is washed, dried and filtered and the ether removed leaving a brown oil of 1-(o-fluorobenzyl)-2[(di-sec-butylamino)acetyl]pyrrole. Infrared and nuclear magnetic resonance spectra confirm this structure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04029672 |
|---|
| 출처 데이터셋 | uspto-grants-1977_06 |
|---|
| ORD ID | ord-4510cb9941db4bcf8af22680c94c132b |
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| 출처 메모 | uspto-grants-1977_06 |
|---|
