反应详情

温度

120 °C

A mixture of 16.0 g of 2-chloroacetyl-1-(o-fluorobenzyl)pyrrole, Example 1a, 8.3 g of di-sec-butylamine and 20.0 g of potassium carbonate in 250 ml xylene is stirred at 120° C. for 72 hours. The mixture is cooled, washed with water, dried and filtered and the xylene is evaporated leaving a brown oil. The oil is dissolved in ether and extracted into a 2N hydrogen chloride solution. The aqueous acidic solution is basified with a sodium carbonate solution and extracted with ether. The ether solution is washed, dried and filtered and the ether removed leaving a brown oil of 1-(o-fluorobenzyl)-2[(di-sec-butylamino)acetyl]pyrrole. Infrared and nuclear magnetic resonance spectra confirm this structure.

1. temperatureThe mixture is cooled
2. washwashed with water
3. customdried
4. filtrationfiltered
5. customthe xylene is evaporated
6. customleaving a brown oil
7. extractionextracted into a 2N hydrogen chloride solution
8. extractionextracted with ether
9. washThe ether solution is washed
10. customdried
11. filtrationfiltered
12. customthe ether removed