Dimethylformamide → HCID 21430457, 화합물
반응식
Cl[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[S:10](=[O:13])(=[O:12])[NH2:11].[CH3:14][N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1.CN(C)C=O>O>[CH3:14][N:15]1[CH2:20][CH2:19][N:18]([C:2]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=2[S:10](=[O:13])(=[O:12])[NH2:11])[CH2:17][CH2:16]1참가 물질
5
실험 절차
43.5 Grams of 4-Chloro-3-sulfamoylbenzonitrile (0.2 mole) were stirred with 45 g of N-methylpiperazine and 50 ml of dimethylformamide for 1 hour at a temperature of from 115° to 120° C., and the reaction solution was subsequently introduced into 0.5 l of water. The crystalline precipitate was suction-filtered, and the moist crude product which had been washed with water, was recrystallized from ethanol.
후처리
- filtrationThe crystalline precipitate was suction-filtered
- washthe moist crude product which had been washed with water
- customwas recrystallized from ethanol
출처 및 근거
- ORD 기록
- ord-1f14858792714fe18746062108a54608
- 출처 데이터셋
- uspto-grants-1977_06
- 특허 번호
- US04029787
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