Sodium Iodide → HCID 14810575, 화합물

HRID 437384

반응식

HRID 437384 반응식
Cl[CH2:2][CH2:3][CH2:4][C:5]([O:7][CH3:8])=[O:6].[CH3:9][C@H:10]1[CH2:15][CH2:14][CH2:13][C@@H:12]([CH3:16])[NH:11]1.[I-].[Na+]>C1(C)C(C)=CC=CC=1>[CH3:9][C@H:10]1[CH2:15][CH2:14][CH2:13][C@@H:12]([CH3:16])[N:11]1[CH2:2][CH2:3][CH2:4][C:5]([O:7][CH3:8])=[O:6]

참가 물질

5

반응물 3

HCID 5238Sodium IodideHCID 76612Butanoic acid, 4-chloro-, methyl esterHCID 641768rel-(2R,6S)-2,6-Dimethylpiperidine

생성물 1

HCID 14810575HCID 14810575, 화합물

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

A mixture of 273 g. of methyl 4-chlorobutyrate, 460 g. of cis-2,6-dimethylpiperidine, 10 g. of sodium iodide and 300 ml. of xylene is stirred and heated at reflux for 44 hours, then cooled and filtered. The filter cake is washed with xylene and the combined filtrate and washings are evaporated at reduced pressure to give cis-2,6-dimethyl-1-piperidinebutyric acid, methyl ester which is purified by distillation; b.p. 79°-81° C./0.5 mm.

후처리

  1. additionA mixture of 273 g
  2. temperatureheated
  3. temperatureat reflux for 44 hours
  4. temperaturecooled
  5. filtrationfiltered
  6. washThe filter cake is washed with xylene
  7. customthe combined filtrate and washings are evaporated at reduced pressure

출처 및 근거

ORD 기록
ord-d2f3b55717314692bbbb371b3e3261ff
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04031101

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