Sodium Iodide → cis-2,6-Dimethyl-1-piperidinebutyric acid, methyl ester
반응식
Cl[CH2:2][CH2:3][CH2:4][C:5]([O:7][CH3:8])=[O:6].[CH3:9][C@H:10]1[CH2:15][CH2:14][CH2:13][C@@H:12]([CH3:16])[NH:11]1.[I-].[Na+]>C1(C)C(C)=CC=CC=1>[CH3:9][C@H:10]1[CH2:15][CH2:14][CH2:13][C@@H:12]([CH3:16])[N:11]1[CH2:2][CH2:3][CH2:4][C:5]([O:7][CH3:8])=[O:6]참가 물질
5
실험 절차
A mixture of 273 g. of methyl 4-chlorobutyrate, 460 g. of cis-2,6-dimethylpiperidine, 10 g. of sodium iodide and 300 ml. of xylene is stirred and heated at reflux for 44 hours, then cooled and filtered. The filter cake is washed with xylene and the combined filtrate and washings are evaporated at reduced pressure to give cis-2,6-dimethyl-1-piperidinebutyric acid, methyl ester which is purified by distillation; b.p. 79°-81° C./0.5 mm.
후처리
- additionA mixture of 273 g
- temperatureheated
- temperatureat reflux for 44 hours
- temperaturecooled
- filtrationfiltered
- washThe filter cake is washed with xylene
- customthe combined filtrate and washings are evaporated at reduced pressure
출처 및 근거
- ORD 기록
- ord-d2f3b55717314692bbbb371b3e3261ff
- 출처 데이터셋
- uspto-grants-1977_06
- 특허 번호
- US04031101
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