2,6-Diaminopyridine → 5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-amine

반응식

[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH2:8])[N:3]=1.[CH2:9]([C:16]([C:18]([F:21])([F:20])[F:19])=O)[C:10]([C:12]([F:15])([F:14])[F:13])=O>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]2[C:4](=[N:8][C:10]([C:12]([F:13])([F:14])[F:15])=[CH:9][C:16]=2[C:18]([F:19])([F:21])[F:20])[N:3]=1

참가 물질

반응물 2

HCID 88612,6-Diaminopyridine

HCID 73706Hexafluoroacetylacetone

생성물 1

HCID 27830715,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-amine

실험 절차

A process as claimed in claim 1 wherein 2,6-diaminopyridine is reacted with 1,1,1,5,5,5-hexafluoroacetylacetone to provide 2-amino-5,7-di(trifluoromethyl)-1,8-naphthyridine.

출처 및 근거

ORD 기록: ord-9783d5eaa771445ab36ce86c1e0c6c74
출처 데이터셋: uspto-grants-1977_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04031103

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