Hydrochloric Acid → 5,6-Dichloro-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyridine
반응식
CNC(O[N:6]1[C:14]2[C:9](=[N:10][CH:11]=[C:12]([Cl:15])[CH:13]=2)[N:8]=[C:7]1[C:16]([F:19])([F:18])[F:17])=O.[ClH:20].O>CO>[Cl:20][C:11]1[N:10]=[C:9]2[N:8]=[C:7]([C:16]([F:19])([F:18])[F:17])[NH:6][C:14]2=[CH:13][C:12]=1[Cl:15]참가 물질
5
실험 절차
1-(Methylcarbamoyloxy)-6-chloro-2-(trifluoromethyl) -1H-imidazo [4,5-b] pyridine (250 milligrams) in 2.5milliliters of methanol was saturated with HCl. The reaction mixture was permitted to stand for three hours, then poured into water and filtered to separate the desired 5,6-dichloro-2-(trifluoromethyl)-1H-imidazo[ 4,5-b] pyridine, m.p., 280° -30° C.
후처리
- filtrationfiltered
- customto separate the desired 5,6-dichloro-2-(trifluoromethyl)-1H-imidazo[ 4,5-b] pyridine, m.p., 280° -30° C.
출처 및 근거
- ORD 기록
- ord-84823d8a2ae84ed3b32c01ada3b536a3
- 출처 데이터셋
- uspto-grants-1977_06
- 특허 번호
- US04031107
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