Bicarbonate Ion → Fluoromidine

HRID 437399

반응식

HRID 437399 반응식
CS(O[N:6]1[C:14]2[C:9](=[N:10][CH:11]=[C:12]([Cl:15])[CH:13]=2)[N:8]=[C:7]1[C:16]([F:19])([F:18])[F:17])(=O)=O.[I-].[Na+].CCOCC.C(=O)(O)[O-]>CC(C)=O>[Cl:15][C:12]1[CH:13]=[C:14]2[NH:6][C:7]([C:16]([F:17])([F:18])[F:19])=[N:8][C:9]2=[N:10][CH:11]=1

참가 물질

6

반응물 4

HCID 769Bicarbonate IonHCID 3283Diethyl EtherHCID 5238Sodium IodideHCID 203599241-(METHYLSULFONYLOXY)-6-CHLORO-2-(TRIFLUOROMETHYL)-1H-IMIDAZO(4,5-b)PYRIDINE

생성물 1

HCID 911208Fluoromidine수율 73%

시약·촉매·용매 1

HCID 180Acetone용매2회

실험 절차

1-(Methylsulfonyloxy)-6-chloro-2-(trifluoromethyl)-1H-imidazo [4,5-b] pyridine (20 milligrams) in 0.5 milliliter of acetone was treated with 0.1 gram of sodium iodide in 0.5 milliliter of acetone. The reaction mixture was shaken with ether and bicarbonate solution. The ether portion was dried over magnesium sulfate and evaporated, yielding 10 milligrams (about 73 percent) of 6-chloro-2-(trifluoromethyl)-1H-imidazo [4,5-b] pyridine.

후처리

  1. dry with materialThe ether portion was dried over magnesium sulfate
  2. customevaporated

출처 및 근거

ORD 기록
ord-fde4c1ece5ef45c68a2011d043d95a1d
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04031107

연결된 노트

불러오는 중…