Phenyl Isothiocyanate → 1-[4-(2-Acetylhydrazino)phenyl]-3-phenylthiourea

HRID 437512

반응식

HRID 437512 반응식
[C:1]([NH:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][CH:7]=1)(=[O:3])[CH3:2].[C:13]1([N:19]=[C:20]=[S:21])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(#N)C>[C:1]([NH:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:20]([NH:19][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[S:21])=[CH:8][CH:7]=1)(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 7673Phenyl IsothiocyanateHCID 81068Acetic acid, 2-(4-aminophenyl)hydrazide

생성물 1

HCID 214278081-[4-(2-Acetylhydrazino)phenyl]-3-phenylthiourea

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

1-Acetyl-2-(4-aminophenyl)hydrazine (8.25 g, 0.05 mole) and phenyl isothiocyanate (6.8 g, 0.05 mole) were suspended in acetonitrile (100 ml). The resulting mixture was heated at reflux with stirring for 5 minutes. The product separated from solution as a white solid. After chilling, the product was removed from the reaction mixture by filtration and washed thoroughly with ether. Yield 14.5 g (96%), m.p. 205°-207° C.

후처리

  1. temperatureThe resulting mixture was heated
  2. temperatureat reflux
  3. customThe product separated from solution as a white solid
  4. temperatureAfter chilling
  5. customthe product was removed from the reaction mixture by filtration
  6. washwashed thoroughly with ether

출처 및 근거

ORD 기록
ord-7c11560f25ad419f81d5494cb785d369
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04031127

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