Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chlorobenzhydryl chloride → 1-(p-Chlorophenyl-phenylmethyl)-3-methyl-3-(3,4-dimethoxybenzyl)-piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chlorobenzhydryl chloride | HCID 241584 | — |
| 반응물 | HCID 20363969 | HCID 20363969 | — |
| 용매 | Methyl Ethyl Ketone | HCID 6569 | — |
| 생성물 | 1-(p-Chlorophenyl-phenylmethyl)-3-methyl-3-(3,4-dimethoxybenzyl)-piperazine | HCID 21428573 | 80% |
반응 단계
If 3-methyl-3-(3,4-dimethoxybenzyl)-piperazine is reacted with p-chlorophenyl-phenylmethyl chloride in methyl ethyl ketone according to Example 2, 1-(p-chlorophenyl-phenylmethyl)-3-methyl-3-(3,4-dimethoxybenzyl)-piperazine is obtained in 80 percent yield after a 12-hour reaction period. The hydrochloride has a melting point of 235°-237° C. (isopropanol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04031216 |
| 출처 데이터셋 | uspto-grants-1977_06 |
| ORD ID | ord-0e0fbab6d28e43e39ecb27d785c875e3 |
| 출처 메모 | uspto-grants-1977_06 |