3-Indoleglyoxylyl chloride → 1-(Indol-3-ylglyoxyloyl)-4-(p-fluorophenoxy)piperidine
반응식
[F:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][CH:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[CH:15]1[CH:20]=[C:19]2[C:21]([C:24]([C:26](Cl)=[O:27])=[O:25])=[CH:22][NH:23][C:18]2=[CH:17][CH:16]=1>>[NH:23]1[C:18]2[C:19](=[CH:20][CH:15]=[CH:16][CH:17]=2)[C:21]([C:24](=[O:25])[C:26]([N:10]2[CH2:9][CH2:8][CH:7]([O:6][C:5]3[CH:13]=[CH:14][C:2]([F:1])=[CH:3][CH:4]=3)[CH2:12][CH2:11]2)=[O:27])=[CH:22]1참가 물질
3
실험 절차
By following the manipulative procedure described in Example 4(b), 4-(p-fluorophenoxy)piperidine is reacted with indole-3-glyoxyloyl chloride to give 1-(indol-3-ylglyoxyloyl)-4-(p-fluorophenoxy)piperidine as an off-white solid. The solid is recrystallized twice from a methanol and water mixture to give white needles of the glyoxamide, m.p. 205°-207° C.
출처 및 근거
- ORD 기록
- ord-6a6ad0c756cf4b878f2a1ef7fb2e16d2
- 출처 데이터셋
- uspto-grants-1977_06
- 특허 번호
- US04031221