Benzoic Acid → 3-(2,4-Bis(diethylamino)phenyl)-3-(4-(dimethylamino)phenyl)phthalide

HRID 437879노트

반응식

HRID 437879 반응식
C(O)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:10]([N:12]([CH2:24][CH3:25])[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([N:19]([CH2:22][CH3:23])[CH2:20][CH3:21])[CH:14]=1)[CH3:11].[C:26]([O:29][C:30](=[O:32])[CH3:31])(=O)[CH3:27]>CO>[CH2:20]([N:19]([CH2:22][CH3:23])[C:15]1[CH:14]=[C:13]([N:12]([CH2:10][CH3:11])[CH2:24][CH3:25])[CH:18]=[CH:17][C:16]=1[C:26]1([C:5]2[CH:4]=[CH:3][C:2]([N:12]([CH3:13])[CH3:10])=[CH:7][CH:6]=2)[C:27]2[C:31](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:30](=[O:32])[O:29]1)[CH3:21]

참가 물질

5

반응물 3

HCID 243Benzoic AcidHCID 7918Acetic AnhydrideHCID 19382815N~1~,N~1~,N~3~,N~3~-Tetraethylbenzene-1,3-diamine

생성물 1

HCID 538941733-(2,4-Bis(diethylamino)phenyl)-3-(4-(dimethylamino)phenyl)phthalide

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
52 °C

실험 절차

A mixture of 2-(4-dimethylamino)benzoyl)benzoic acid (8.07 g.), N,N,N',N'-tetraethyl-m-phenylenediamine (7.26 g.) and acetic anhydride (5 ml.) was heated (at 52° C.) during one and one-half hours. Addition of methanol (10 ml., then 15 ml.) afforded 3-(2,4-bis(diethylamino)phenyl)-3-(4-(dimethylamino)phenyl)phthalide (I: X= (CH3CH2)2N, Y2 = Z4 = Z5 = Z6 = Z7 = H, Y4 = (CH3)2N) (10.92 g., m.p. 117°- 119° C.).

출처 및 근거

ORD 기록
ord-f3142030a80c428ab38720aeb89ea988
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04032527

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