Hydrochloric Acid → 2,3,4,4a-Tetrahydro-1H-pyrazino(1,2a)quinoxalin-5-(6H)one

HRID 437952노트

반응식

HRID 437952 반응식
C([N:11]1[CH2:25][CH2:24][N:14]2[C:15]3[C:20]([NH:21][C:22](=[O:23])[CH:13]2[CH2:12]1)=[CH:19][CH:18]=[CH:17][CH:16]=3)(OCC1C=CC=CC=1)=O.Cl.[H][H]>[Pd].C(O)C>[CH2:24]1[N:14]2[C:15]3[C:20]([NH:21][C:22](=[O:23])[CH:13]2[CH2:12][NH:11][CH2:25]1)=[CH:19][CH:18]=[CH:17][CH:16]=3

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 121096443-benzyloxycarbonyl-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-oneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 1563622,3,4,4a-Tetrahydro-1H-pyrazino(1,2a)quinoxalin-5-(6H)one

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 3.0 g. of 3carbobenzoxy-2,3,4,4 a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one, 2 g. of hydrogen chloride, 3 g. of 10% palladium on carbon and 200 ml. of ethanol is hydrogenated on a Parr apparatus for 18 hours at 46 p.s.i. hydrogen pressure. The catalyst is filtered and the filtrate is concentrated. The residue is recrystallized from ethanol to give 0.55 g. of the product as the hydrogen chloride salt, m.p. 288°-290° .

후처리

  1. additionA mixture of 3.0 g
  2. filtrationThe catalyst is filtered
  3. concentrationthe filtrate is concentrated
  4. customThe residue is recrystallized from ethanol
  5. customto give 0.55 g

출처 및 근거

ORD 기록
ord-92ac0ea521b34a31aab7bcfc135b25a4
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04032639

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