Water → 1,2,3,9-Tetrahydro-6-methoxy-9-methyl-4H-carbazol-4-one

HRID 4380

반응식

HRID 4380 반응식
[C:1](=O)([O-])[O-].[K+].[K+].[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17]1[CH2:16][CH2:15][CH2:14][C:13](=[O:22])[C:12]2=1.S(OC)(OC)(=O)=O.O>CC(C)=O>[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[C:19](=[CH:20][CH:21]=1)[N:18]([CH3:1])[C:17]1[CH2:16][CH2:15][CH2:14][C:13](=[O:22])[C:12]2=1

참가 물질

6

반응물 4

HCID 962WaterHCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 152128016-Methoxy-1,2,3,9-tetrahydro-4H-carbazol-4-one

생성물 1

HCID 197698301,2,3,9-Tetrahydro-6-methoxy-9-methyl-4H-carbazol-4-one수율 78.2%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Anhydrous potassium carbonate (2.24 g) was added to a solution of the product of Stage (i) (3 g) in acetone (30 ml) at room temperature and stirred for 30 min. Dimethyl sulphate (1.6 ml) was added and the mixture was heated to reflux for 4 h. The resulting solution was poured into water (150 ml) and the resulting precipitate filtered off to give the title compound as a solid (2.5 g), m.p. 150°-151°.

후처리

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 4 h
  3. filtrationthe resulting precipitate filtered off

출처 및 근거

ORD 기록
ord-1ac4895b46ac455b903ac181d0e5e30d
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04725615

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