Staurosporine → Biphenyl

HRID 438035

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HRID 438035 반응식
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4.N#Cc1ccc(C=O)cc1Br>CC(=O)N(C)C.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].[Na+].[Ti+4]>CO[C@@H]1[C@H](N(C)Cc2ccc(C#N)c(Br)c2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4

참가 물질

10

반응물 2

HCID 44259StaurosporineHCID 534255192-Bromo-4-formylbenzonitrile

생성물 4

HCID 7095BiphenylHCID 44259StaurosporineHCID 2884342-Bromo-4-(hydroxymethyl)benzonitrileHCID 178496679HCID 178496679, 화합물

시약·촉매·용매 4

HCID 176Acetic Acid시약HCID 11026Titanium isopropoxide시약HCID 5049666Sodium triacetoxyborohydride시약HCID 31374Dimethylacetamide용매7회

반응 조건

온도
22 °C

후처리

  1. additionThe next morning, the Mosquito(R) was used to dilute the 100 mM reactions to 50 mM via addition of 1 uL DMSO to each reaction well, followed by dispense mixing.
  2. additionThe reactions were diluted with 3x1 uL DMSO (containing PhPh as an internal standard) using the Mosquito(R). The reactions were mixed after each dispense operation.
  3. aliquotMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis by UPLC.
  4. additionMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis by UPLC.

출처 및 근거

ORD 기록
ord-ca354b274f7b4e9f919ece02d5f381f4
출처 데이터셋
Cernak miniaturized reductive amination
원본 링크
출처 보기

연결된 노트

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