3,4-Dimethylbenzaldehyde → Biphenyl

HRID 438080

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HRID 438080 반응식
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4.Cc1ccc(C=O)cc1C>CC(=O)N(C)C.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].[Na+].[Ti+4]>CO[C@@H]1[C@H](N(C)Cc2ccc(C)c(C)c2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4

참가 물질

10

반응물 2

HCID 222783,4-DimethylbenzaldehydeHCID 44259Staurosporine

생성물 4

HCID 7095BiphenylHCID 234073,4-Dimethylbenzyl alcoholHCID 44259StaurosporineHCID 178496676HCID 178496676, 화합물

시약·촉매·용매 4

HCID 176Acetic Acid시약HCID 11026Titanium isopropoxide시약HCID 5049666Sodium triacetoxyborohydride시약HCID 31374Dimethylacetamide용매7회

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온도
22 °C

후처리

  1. additionThe next morning, the Mosquito(R) was used to dilute the 100 mM reactions to 50 mM via addition of 1 uL DMSO to each reaction well, followed by dispense mixing.
  2. additionThe reactions were diluted with 3x1 uL DMSO (containing PhPh as an internal standard) using the Mosquito(R). The reactions were mixed after each dispense operation.
  3. aliquotMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis by UPLC.
  4. additionMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis by UPLC.

출처 및 근거

ORD 기록
ord-0001c68b507344ecbe1e52f457f8e635
출처 데이터셋
Cernak miniaturized reductive amination
원본 링크
출처 보기

연결된 노트

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