Diisopropylethylamine → Ethyl 2-{3-[(tert-butoxycarbonyl)amino]azetidin-1-yl)-4-n-butyl-1,3-thiazole-5-carboxylate

HRID 43880

반응식

HRID 43880 반응식
[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:12][NH:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[C:14]1[S:15][C:16]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[C:17]([CH2:19][CH2:20][CH2:21][CH3:22])[N:18]=1.C(N(C(C)C)CC)(C)C>>[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:10][N:11]([C:14]2[S:15][C:16]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[C:17]([CH2:19][CH2:20][CH2:21][CH3:22])[N:18]=2)[CH2:12]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 3

HCID 81531DiisopropylethylamineHCID 15194053-Aminoazetidine, 3-BOC protectedHCID 67549203Ethyl 2-bromo-4-n-butyl-1,3-thiazole-5-carboxylate

생성물 1

HCID 67548951Ethyl 2-{3-[(tert-butoxycarbonyl)amino]azetidin-1-yl)-4-n-butyl-1,3-thiazole-5-carboxylate수율 74.4%

실험 절차

The same operation as in Example (217a) was performed using 3-tert-butoxycarbonylaminoazetidine (212 mg, 1.23 mmol), ethyl 2-bromo-4-n-butyl-1,3-thiazole-5-carboxylate obtained in Example (220b) (300 mg, 1.03 mmol) and diisopropylethylamine (0.36 mL, 2.06 mmol), to obtain 294 mg of the title compound as a white solid (74%).

출처 및 근거

ORD 기록
ord-2e2a985ed8fb4f6ba1c706102444b688
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536197B2

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