Diisopropylethylamine → HCID 67549359, 화합물

HRID 43902노트

반응식

HRID 43902 반응식
[C:1]([O:5][C:6]([N:8]([CH3:13])[CH:9]1[CH2:12][NH:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[C:15]1[S:16][C:17]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[C:18]([CH3:20])[N:19]=1.C(N(C(C)C)CC)(C)C>>[C:1]([O:5][C:6]([N:8]([CH3:13])[CH:9]1[CH2:10][N:11]([C:15]2[S:16][C:17]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[C:18]([CH3:20])[N:19]=2)[CH2:12]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 3

HCID 81531DiisopropylethylamineHCID 2824057Ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylateHCID 23033645tert-Butyl azetidin-3-yl(methyl)carbamate

생성물 1

HCID 67549359HCID 67549359, 화합물수율 70.9%

실험 절차

The same operation as in Example (217a) was performed using 3-[(tert-butoxycarbonyl)(methyl)amino]azetidine (1.31 g, 7.03 mmol), ethyl 2-bromo-4-methylthiazole-5-carboxylate (134 mg, 0.54 mmol) and diisopropylethylamine (0.19 mL, 1.07 mmol), to obtain 136 mg of the title compound as a colorless oily substance (72%).

출처 및 근거

ORD 기록
ord-aabd3876d3604506951c470a6e72759f
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536197B2

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