Diisopropylethylamine → Ethyl 2-(4-aminopiperidin-1-yl)-4-methyl-1,3-thiazole-5-carboxylate

HRID 43931

반응식

HRID 43931 반응식
[NH2:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Br[C:9]1[S:10][C:11]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:12]([CH3:14])[N:13]=1.C(N(C(C)C)CC)(C)C>>[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([C:9]2[S:10][C:11]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:12]([CH3:14])[N:13]=2)[CH2:4][CH2:3]1

참가 물질

4

반응물 3

HCID 81531DiisopropylethylamineHCID 4243614-PiperidinamineHCID 2824057Ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate

생성물 1

HCID 67548556Ethyl 2-(4-aminopiperidin-1-yl)-4-methyl-1,3-thiazole-5-carboxylate수율 87.6%

실험 절차

The same operation as in Example (237a) was performed using 4-aminopiperidine (0.19 mL, 1.80 mmol), ethyl 2-bromo-4-methylthiazole-5-carboxylate (300 mg, 1.20 mmol) and diisopropylethylamine (0.42 mL, 2.40 mmol), to obtain 283 mg of the title compound as a pale yellow oily substance (88%).

출처 및 근거

ORD 기록
ord-73afe5373f8742218418f04cf9ebd489
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536197B2

연결된 노트

불러오는 중…