N-[4-fluoro-2-nitro-6-(trifluoromethyl)phenyl]acetamide → 4-Fluoro-2-nitro-6-(trifluoromethyl)aniline

HRID 439495노트

반응식

HRID 439495 반응식
C([NH:4][C:5]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:8]([F:14])=[CH:7][C:6]=1[C:15]([F:18])([F:17])[F:16])(=O)C>Cl>[NH2:4][C:5]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:8]([F:14])=[CH:7][C:6]=1[C:15]([F:18])([F:16])[F:17]

참가 물질

3

반응물 1

HCID 10778132N-[4-fluoro-2-nitro-6-(trifluoromethyl)phenyl]acetamide

생성물 1

HCID 2230974-Fluoro-2-nitro-6-(trifluoromethyl)aniline수율 50%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A mixture of 2-acetamido-5-fluoro-3-nitrobenzotrifluoride (1.50 g, 5.64 mmol) in concentrated HCl (10 mL) was refluxed overnight and it was extracted by ethyl acetate (2×10 mL). The extract was dried over Mg2SO4, and evaporated to give 624 mg of 2-amino-5-fluoro-3-nitrobenzotrifluoride (50%). 1H NMR (CDCl3): δ6.547 (s, 2H), 7.570 (dd, 1H, J1 =2.7 Hz, J2 =5.7 Hz), 8.114 (dd, 1 H, J1 =2.7 Hz, J2 =5.7 Hz).

후처리

  1. temperaturewas refluxed overnight
  2. extractionit was extracted by ethyl acetate (2×10 mL)
  3. dry with materialThe extract was dried over Mg2SO4
  4. customevaporated

출처 및 근거

ORD 기록
ord-af29ebff411b46629fc9dc6257e77d9b
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05514680

반응 노트

불러오는 중…