Ethanol → 5-bromo-2-butyl-1H-imidazole-4-methanol

HRID 439607노트

반응식

HRID 439607 반응식
[Br:1]N1C(=O)CCC1=O.[CH2:9]([C:13]1[NH:14][C:15]([CH2:20][OH:21])=[C:16](CO)[N:17]=1)[CH2:10][CH2:11][CH3:12].C(O)C>O1CCOCC1>[CH2:9]([C:13]1[NH:14][C:15]([CH2:20][OH:21])=[C:16]([Br:1])[N:17]=1)[CH2:10][CH2:11][CH3:12]

참가 물질

5

반응물 3

HCID 702EthanolHCID 67184N-bromobutanimideHCID 15338146(2-butyl-1H-imidazole-4,5-diyl)dimethanol

생성물 1

HCID 99915715-bromo-2-butyl-1H-imidazole-4-methanol

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

3.56 Grams (20 mmol) of the N-bromosuccinimide was added to a solution consisting of 3.68 g (20.0 mmol) of the 2-butyl-4,5-bis(hydroxymethyl) imidazole, 40 ml of ethanol and 15 ml of dioxane maintained at a temperature of 45° to 50° C. with stirring. The mixture was further reacted at the same temperature for 30 minutes with stirring, and then the solvent was distilled off under reduced pressure. The obtained reaction product was washed with water and was recrystallized from acetonitrile to obtain a pale yellowish scale-like crystalline 2-butyl-4-bromo-5-(hydroxymethyl) imidazole in an amount of 2.36 g (yield, 51%).

후처리

  1. temperaturemaintained at a temperature of 45° to 50° C.
  2. customThe mixture was further reacted at the same temperature for 30 minutes
  3. stirringwith stirring
  4. distillationthe solvent was distilled off under reduced pressure
  5. customThe obtained reaction product
  6. washwas washed with water
  7. customwas recrystallized from acetonitrile

출처 및 근거

ORD 기록
ord-025b73636d7a460a9c2331cb9ff512a5
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05514811

반응 노트

불러오는 중…