3-Heptanone → HCID 252033, 화합물

HRID 439610

반응식

HRID 439610 반응식
[CH3:1][CH2:2][C:3](=O)[CH2:4][CH2:5][CH2:6][CH3:7].Cl.[NH2:10][OH:11]>CO>[CH3:1][CH2:2][C:3](=[N:10][OH:11])[CH2:4][CH2:5][CH2:6][CH3:7]

참가 물질

4

반응물 2

HCID 78023-HeptanoneHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 252033HCID 252033, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 1-azabicyclo 2.2.1!heptan-3-one (8.83 g, 79 mmol) and hydroxylamine hydrochloride (5.52 g, 79 mmol) in MeOH (200 mL) was stirred at 25° C. for 18 hours. The solvent was removed under reduced pressure and the tan solid was partitioned between saturated Na2CO3 and CHCl3. The organic extracts were dried (Na2CO3), and concentrated to give the oxime, 5.48 g, 54.7%. The aqueous layer was concentrated, and re-extracted with CHCl3 to yield another 3.17 g product. Total yield, 8.65 g, 86%. The ratio is from 95% to 98% Z to E.

후처리

  1. additionA mixture of 1-azabicyclo 2.2.1
  2. customThe solvent was removed under reduced pressure
  3. customthe tan solid was partitioned between saturated Na2CO3 and CHCl3
  4. dry with materialThe organic extracts were dried (Na2CO3)
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c93303fc8c2e49a689a553bfe5c8f4fa
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05514812

연결된 노트

불러오는 중…