Sodium borohydride → 4-Bromo-3-chloro-3,4,4-trifluorobutan-1-ol

HRID 439663

반응식

HRID 439663 반응식
[Br:1][C:2]([F:10])([F:9])[C:3]([Cl:8])([F:7])[CH2:4][CH:5]=[O:6].[BH4-].[Na+]>>[Br:1][C:2]([F:10])([F:9])[C:3]([Cl:8])([F:7])[CH2:4][CH2:5][OH:6]

참가 물질

3

반응물 2

HCID 4311764Sodium borohydrideHCID 218364804-Bromo-3-chloro-3,4,4-trifluorobutanal

생성물 1

HCID 218364774-Bromo-3-chloro-3,4,4-trifluorobutan-1-ol

실험 절차

Alternatively, the intermediate VII can be reduced with sodium borohydride without isolation to give 4-bromo-3-chloro-3,4,4-trifluorobutanol ((IX) in high yield; or by hydrolysis of 1,4-dibromo-2-chloro-1,1,2-trifluorobutane (XVI) to give IX. Oxidation of IX with Jones reagent to give VIII in 85% yield.

출처 및 근거

ORD 기록
ord-7b1c9b35e2d64ea98dcf2ea9f2964ba7
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05514717

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