3-Bromo-1-propanol → 3-[3-(Pentyloxy)phenoxy]propanol

HRID 439753노트

반응식

HRID 439753 반응식
[H-].[Na+].[CH2:3]([O:8][C:9]1[CH:10]=[C:11]([OH:15])[CH:12]=[CH:13][CH:14]=1)[CH2:4][CH2:5][CH2:6][CH3:7].Br[CH2:17][CH2:18][CH2:19][OH:20]>CN(C)C=O>[CH2:3]([O:8][C:9]1[CH:10]=[C:11]([CH:12]=[CH:13][CH:14]=1)[O:15][CH2:17][CH2:18][CH2:19][OH:20])[CH2:4][CH2:5][CH2:6][CH3:7]

참가 물질

5

반응물 3

HCID 123083-Bromo-1-propanolHCID 24758Sodium hydrideHCID 156922293-(Pentyloxy)phenol

생성물 1

HCID 224080143-[3-(Pentyloxy)phenoxy]propanol

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

A mixture of 0.80 g of 60% NaH in 28 ml of anhydrous dimethylformamide is cooled in an ice bath. To this is added 3.01 g of the above 3-pentyloxyphenol oil dissolved in 7 ml of anhydrous dimethylformamide. This mixture is then stirred at room temperature for 45 minutes; 1.81 ml of 3-Bromopropanol are added; and the resultant mixture is stirred at 60° C. for 17 hours. The solvent is removed under vacuum, and the residue worked up in same manner as above. The residue obtained is flash chromatographed on normal phase silica gel eluting with a 3:2 ratio of hexane:ether to yield 3-[3-(pentyloxy)phenoxy]propanol as a pale yellow oil.

후처리

  1. temperatureis cooled in an ice bath
  2. customThe solvent is removed under vacuum
  3. customThe residue obtained
  4. customchromatographed on normal phase silica gel eluting with a 3:2 ratio of hexane

출처 및 근거

ORD 기록
ord-953d1a9f5ed04b66a2fcdd26a50d1535
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05516767

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