Trifluoroacetic acid → Methyl 4-(4-methoxyphenylmethyl)benzoate

HRID 439793노트

반응식

HRID 439793 반응식
[BH4-].[Na+].FC(F)(F)C(O)=O.[CH3:10][O:11][C:12]([C:14]1[CH:29]=[CH:28][C:17]([C:18]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=2)=O)=[CH:16][CH:15]=1)=[O:13]>C(Cl)Cl>[CH3:27][O:26][C:23]1[CH:22]=[CH:21][C:20]([CH2:18][C:17]2[CH:28]=[CH:29][C:14]([C:12]([O:11][CH3:10])=[O:13])=[CH:15][CH:16]=2)=[CH:25][CH:24]=1

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 257913Benzoic acid, 4-(4-methoxybenzoyl)-, methyl esterHCID 4311764Sodium borohydride

생성물 1

HCID 22408239Methyl 4-(4-methoxyphenylmethyl)benzoate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a mixture of sodium borohydride (2.27 g) and trifluoroacetic acid (50 ml), which was previously prepared under nitrgen atmosphere, was added a solution of 4-methoxycarbonyl-4'-methoxybenzophenone (2.70 g) and methylene chloride (30 ml) at room temperature. After reacting for 24 hours, the reaciton mixture was poured into ice-water, and methylene chloride layer was sepatated. Water layer was further extracted with methylene chloride (50 ml×2).

후처리

  1. customwas previously prepared under nitrgen atmosphere
  2. extractionWater layer was further extracted with methylene chloride (50 ml×2)

출처 및 근거

ORD 기록
ord-ed48e658f15341269af77a0bbdc8401d
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05516777

반응 노트

불러오는 중…