Sodium Bicarbonate → (S)-Benzyl piperidine-2-carboxylate

HRID 439818

반응식

HRID 439818 반응식
[NH:1]1[CH2:16][CH2:15][CH2:14][CH2:13][CH:2]1[C:3]([O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:4].C(=O)(O)[O-].[Na+]>C(OCC)(=O)C>[NH:1]1[CH2:16][CH2:15][CH2:14][CH2:13][C@H:2]1[C:3]([O:5][CH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1)=[O:4]

참가 물질

4

반응물 2

HCID 516892Sodium BicarbonateHCID 12436232Benzyl piperidine-2-carboxylate

생성물 1

HCID 12436231(S)-Benzyl piperidine-2-carboxylate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Benzyl pipecolate was routinely generated by treating an ethyl acetate suspension of this salt with saturated sodium bicarbonate until dissolution of the organic material. The aqueous layer was extracted twice with ethyl acetate and the combined organic extracts were dried with MgSO4 and evaporated to yield (S)-Benzyl pipecolate (133) as a pale yellow oil.

후처리

  1. additionby treating
  2. dissolutionuntil dissolution of the organic material
  3. extractionThe aqueous layer was extracted twice with ethyl acetate
  4. dry with materialthe combined organic extracts were dried with MgSO4
  5. customevaporated

출처 및 근거

ORD 기록
ord-a1a196c1d37c4c3f9bf2e3b0eeb99535
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05516797

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