1-(3-Nitropyridin-2-yl)piperazine → 2-(Piperazin-1-yl)pyridin-3-amine

HRID 440244

반응식

HRID 440244 반응식
[N+:1]([C:4]1[C:5]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[N:6][CH:7]=[CH:8][CH:9]=1)([O-])=O.[H][H]>CO.[C].[Pd]>[NH2:1][C:4]1[C:5]([N:10]2[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]2)=[N:6][CH:7]=[CH:8][CH:9]=1

참가 물질

5

반응물 2

HCID 37788341-(3-Nitropyridin-2-yl)piperazineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 103973582-(Piperazin-1-yl)pyridin-3-amine수율 95.8%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

In 30 ml of methanol was dissolved 3.13 g (0.015 mole) of 1-(3-nitro-2-pyridyl)piperazine, and 2 g of 5% palladium carbon was added thereto. While stirring the mixture at room temperature, hydrogen gas was passed through for one hour. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to obtain 2.56 g of 1-(3-amino-2-pyridyl)piperazine as pale yellow liquid.

후처리

  1. additionwas added
  2. customwas passed through for one hour
  3. filtrationThe reaction mixture was filtered
  4. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ddd5187149e74fe9b7a86c02188a48f5
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05519016

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