Bromine → 2-Bromo-1-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethan-1-one

HRID 4403

반응식

HRID 4403 반응식
[C:1]([C:4]1[N:5]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[O:7][C:8]=1[CH3:9])(=[O:3])[CH3:2].[Br:16]Br.C(=O)(O)[O-].[Na+]>C(Cl)(Cl)Cl>[Br:16][CH2:2][C:1]([C:4]1[N:5]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[O:7][C:8]=1[CH3:9])=[O:3]

참가 물질

5

반응물 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 123378491-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethan-1-one

생성물 1

HCID 149136502-Bromo-1-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethan-1-one수율 86.8%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

반응 조건

온도
55 °C

실험 절차

To a stirred solution of 4-acetyl-5-methyl-2-phenyloxazole (12.0 g) in chloroform (100 ml) was added at 50° C. a solution of bromine (10.5 g) in chloroform (10 ml). The mixture was further heated at 55° C. for 30 minutes and poured into saturated aqueous sodium bicarbonate solution (500 ml). The chloroform layer was separated and the aqueous layer was extracted with chloroform. The conbined chloroform layer was washed with water and dried (MgSO4). Evaporation of the solvent gave 4-bromoacetyl-5-methyl-2-phenyloxazole as crystals (14.5 g, 86.3%). Recrystallization from ethyl ether-hexane gave colorless rods, mp 88°-89° C.

후처리

  1. customThe chloroform layer was separated
  2. extractionthe aqueous layer was extracted with chloroform
  3. washThe conbined chloroform layer was washed with water
  4. dry with materialdried (MgSO4)
  5. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-fa6b00b25d154a97988b043a2abfac3a
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04725610

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