Isopropanol → Tert-butyl 2-bromo-2-(diethoxyphosphoryl)acetate

HRID 440388노트

반응식

HRID 440388 반응식
[CH2:1]([O:3][P:4]([C:9](Br)([Br:17])[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])([O:6][CH2:7][CH3:8])=[O:5])[CH3:2].C(O)(C)C.[Sn](Cl)Cl>O>[CH2:1]([O:3][P:4]([CH:9]([Br:17])[C:10]([O:12][C:13]([CH3:14])([CH3:16])[CH3:15])=[O:11])([O:6][CH2:7][CH3:8])=[O:5])[CH3:2]

참가 물질

5

반응물 3

HCID 3776IsopropanolHCID 24479Stannous ChlorideHCID 21263367HCID 21263367, 화합물

생성물 1

HCID 21263365Tert-butyl 2-bromo-2-(diethoxyphosphoryl)acetate

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
0 °C

실험 절차

Combine t-butyl diethylphosphonodibromoacetate (75.6 g, 184 mmol) and isopropanol (190 mL). Cool to 0° C. Add a solution of tin (II) chloride (33.2 g, 175 mmol) in water (190 mL). After the addition is complete, warm to ambient temperature. After 1 hour, extract the reaction mixture three times with chloroform. Combine the organic layers and extract with water, dry over MgSO4, filter, and evaporate in vacuo to give the title compound.

후처리

  1. additionAfter the addition
  2. temperaturewarm to ambient temperature
  3. extractionextract the reaction mixture three times with chloroform
  4. extractionextract with water
  5. dry with materialdry over MgSO4
  6. filtrationfilter
  7. customevaporate in vacuo

출처 및 근거

ORD 기록
ord-731871366ac4462d81e184affa73d2c1
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05519048

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