3-Chlorophenol → 4-(3-Chlorophenoxy)benzaldehyde
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.F[C:10]1[CH:17]=[CH:16][C:13]([CH:14]=[O:15])=[CH:12][CH:11]=1.[H-].[Na+]>CN(C)C=O.O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][CH:7]=1)[O:8][C:10]1[CH:17]=[CH:16][C:13]([CH:14]=[O:15])=[CH:12][CH:11]=1참가 물질
6
실험 절차
3-Chlorophenol (1.9 g) was stirred with 4-fluoro-benzaldehyde (1.8 g) and sodium hydride (0.46 g of an 80% suspension in oil) in dimethylformamide (50 ml) at 110° C. under an atmosphere of nitrogen for 16 hours. The solution was diluted with water and extracted with diethyl ether. The ethereal extract was dried (Na2SO4), concentrated and purified by chromatography on silica gel eluting with ethyl acetate-petroleum ether (1:9) to give the title compound as a colourless oil.
후처리
- extractionextracted with diethyl ether
- extractionThe ethereal extract
- dry with materialwas dried (Na2SO4)
- concentrationconcentrated
- custompurified by chromatography on silica gel eluting with ethyl acetate-petroleum ether (1:9)
출처 및 근거
- ORD 기록
- ord-adf6b17e5a4a457bb97a4f58c785175d
- 출처 데이터셋
- uspto-grants-1996_05
- 특허 번호
- US05519163
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