Sulfuric Acid → 7-Nitrobenzofuran-3(2H)-one

HRID 440672노트

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HRID 440672 반응식
[N+:1]([C:4]1[C:12]2[O:11][CH:10](C(OCC)=O)[C:9](=[O:18])[C:8]=2[CH:7]=[CH:6][CH:5]=1)([O-:3])=[O:2].[OH-].[Na+].S(=O)(=O)(O)O>>[N+:1]([C:4]1[C:12]2[O:11][CH2:10][C:9](=[O:18])[C:8]=2[CH:7]=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

4

반응물 3

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 22404730Ethyl 2,3-dihydro-7-nitrobenzofuran-3-on-2-ylcarboxylate

생성물 1

HCID 224047597-Nitrobenzofuran-3(2H)-one

실험 절차

In a flask 3.77 g (0.015 mole) of ethyl 2,3-dihydro-7-nitrobenzofuran-3-on-2-ylcarboxylate is suspended in 75 mL of a 5% aqueous solution of sodium hydroxide which is heated at reflux until all solid has gone into solution. The solution is cooled to ambient temperature, and dilute sulfuric acid is added cautiously until there is no further evidence of decarboxylation. The product is extracted with ethyl acetate, and the combined extracts are dried over anhydrous magnesium sulfate and filtered. The filtrate is evaporated under reduced pressure, leaving 2,3-dihydro-7-nitro-3-benzofuranone as a residue.

후처리

  1. temperatureis heated
  2. temperatureat reflux until all solid
  3. extractionThe product is extracted with ethyl acetate
  4. dry with materialthe combined extracts are dried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. customThe filtrate is evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-ae92de2aaec94a80a92b0831b3386e8d
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05521147

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