Methyl 6-thien-2-ylnicotinate → 6-(Thiophen-2-Yl)Pyridine-3-Carboxylic Acid

HRID 440766

반응식

HRID 440766 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:11]=[CH:10][C:9]([C:12]([O:14]C)=[O:13])=[CH:8][CH:7]=1>CO.[OH-].[Na+]>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:11]=[CH:10][C:9]([C:12]([OH:14])=[O:13])=[CH:8][CH:7]=1

참가 물질

4

반응물 1

HCID 17879034Methyl 6-thien-2-ylnicotinate

생성물 1

HCID 154111446-(Thiophen-2-Yl)Pyridine-3-Carboxylic Acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 14798Sodium Hydroxide용매

실험 절차

A solution of 2.0 g of methyl 6-(2-thienyl)pyridine-3-carboxylate in 100 ml of methyl alcohol and 50 ml of 5N sodium hydroxide is stirred at room temperature for 16 hours under nitrogen. The reaction mixture is evaporated in vacuo to about one quarter of the volume and then diluted with 150 ml of cold water. The pH is adjusted to 4 with acetic acid and the desired white product collected, washed with 400 ml of cold water until neutral. The solid is washed with 50 ml of petroleum ether and dried under vacuum to 40° C. to give the desired product.

후처리

  1. customThe reaction mixture is evaporated in vacuo to about one quarter of the volume
  2. additiondiluted with 150 ml of cold water
  3. customthe desired white product collected
  4. washwashed with 400 ml of cold water until neutral
  5. washThe solid is washed with 50 ml of petroleum ether
  6. customdried under vacuum to 40° C.

출처 및 근거

ORD 기록
ord-99a7d22472914ee8a67a8d1bd0cba47d
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05521173

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