Diisopropylamine → 2-Cyano-6-phenyl-1-hexen-1-ol

A stirred solution of 2.2 mL (0.016 mole) of diisopropylamine in 200 mL of tetrahydrofuran was cooled to -80° C., and 6.4 mL (0.016 mole) of n-butyllithium (2.5 Molar in hexanes) was added dropwise during a 15 minute period. Upon completion of addition, the reaction mixture was stirred for an additional 15 minutes. While still maintaining the reaction mixture temperature at -80° C. to -75° C., a solution of 2.5 grams (0.016 mole) of 6-phenylhexanenitrile in 50 mL of tetrahydrofuran was added dropwise during a 30 minute period. Upon completion of addition, the reaction mixture was stirred at -80° C. for an additional 30 minutes. After this time, a solution of 1.3 mL (0.016 mole) of ethyl formate in 50 mL of tetrahydrofuran was added dropwise during a ten minute period. Upon completion of addition, the reaction mixture was stirred for two hours at -80° C. to -70° C. The reaction was quenched with 100 mL of water, and the mixture was acidified with 6N hydrochloric acid. The mixture was extracted with two 150 mL portions of diethyl ether. The combined extracts were dried with magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to a residue. The residue was subjected to column chromatography using silica gel. Elution was accomplished using 1% to 3% methanol in methylene chloride. The appropriate fractions were combined and concentrated under reduced pressure, yielding 2.7 grams of 2-cyano-6-phenyl-1-hexen-1-ol. The NMR spectrum was consistent with the proposed structure.

1. additionUpon completion of addition
2. temperatureWhile still maintaining the reaction mixture temperature at -80° C. to -75° C.
3. additionUpon completion of addition
4. stirringthe reaction mixture was stirred at -80° C. for an additional 30 minutes
5. additionUpon completion of addition
6. stirringthe reaction mixture was stirred for two hours at -80° C. to -70° C
7. customThe reaction was quenched with 100 mL of water
8. extractionThe mixture was extracted with two 150 mL portions of diethyl ether
9. dry with materialThe combined extracts were dried with magnesium sulfate
10. filtrationfiltered
11. concentrationThe filtrate was concentrated under reduced pressure to a residue
12. washElution
13. concentrationconcentrated under reduced pressure

ORD 기록

ord-b8ad438949bb4a30bed7068be41d01bd

출처 데이터셋

uspto-grants-1996_05

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US05521192