Water → 3-Iodo-4-methylbenzoic acid

HRID 44106

반응식

HRID 44106 반응식
C[O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[C:6]([I:11])[CH:5]=1.[OH-].[Na+].O>CO>[I:11][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[CH3:10])[C:3]([OH:12])=[O:2]

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 13614033Methyl 3-iodo-4-methylbenzoate

생성물 1

HCID 6216403-Iodo-4-methylbenzoic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl-3-Iodo-4-methylbenzoate (3 g, 109 mmol, 1 eq) dissolved in MeOH (30 ml) was added sodium hydroxide (1.3 g, 327 mmol, 3 eq) followed by the addition of water (15 ml). The above solution was stirred at room temperature for 14 h. The solution was concentrated under vacuum, and then added water. The pH of the reaction was bought to 3 using Conc.HCl. The solid obtained was filtered and dried under vacuum. Yield: 2.7 g (96%). 1HNMR (400 MHz, DMSO-d6): δ 2.44 (s, 3H), 7.45 (d, J=8.00 Hz, 1H), 7.85 (d, J=3.18 Hz, 1H), 8.31 (s, 1H).

후처리

  1. concentrationThe solution was concentrated under vacuum
  2. customThe solid obtained
  3. filtrationwas filtered
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-4e88ff1604a94ca7b5dd632420ca3b1e
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536338B2

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