Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 1-{4-[2-(2-Carboxyphenyl)benzoylamino]benzoyl}-1,2,3,4-tetrahydroquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Diphenic anhydride | HCID 72794 | — |
| 반응물 | (4-aminophenyl)(3,4-dihydroquinolin-1(2H)-yl)methanone | HCID 2984117 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-{4-[2-(2-Carboxyphenyl)benzoylamino]benzoyl}-1,2,3,4-tetrahydroquinoline | HCID 22405102 | 84% |
반응 단계
A mixture of 1-(4-aminobenzoyl)-1,2,3,4-tetrahydroquinoline (252 mg), diphenic anhydride (224 mg), triethylamine (202 mg) and catalytic amount of 4-dimethylaminopyridine in dichloromethane (15 ml) was stirred for 8 hours at ambient temperature. The mixture was evaporated in vacuo and diluted with ethyl acetate and washed with saturated sodium hydrogen carbonate aqueous solution, brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo and triturated from ethyl acetate to give 1-{4-[2-(2-carboxyphenyl)benzoylamino]benzoyl}-1,2,3,4-tetrahydroquinoline (400 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05521170 |
| 출처 데이터셋 | uspto-grants-1996_05 |
| ORD ID | ord-0cfb53e26d7849009cbdc96b6092b079 |
| 출처 메모 | uspto-grants-1996_05 |