反应详情

A mixture of 1-(4-aminobenzoyl)-1,2,3,4-tetrahydroquinoline (252 mg), diphenic anhydride (224 mg), triethylamine (202 mg) and catalytic amount of 4-dimethylaminopyridine in dichloromethane (15 ml) was stirred for 8 hours at ambient temperature. The mixture was evaporated in vacuo and diluted with ethyl acetate and washed with saturated sodium hydrogen carbonate aqueous solution, brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo and triturated from ethyl acetate to give 1-{4-[2-(2-carboxyphenyl)benzoylamino]benzoyl}-1,2,3,4-tetrahydroquinoline (400 mg).

1. customThe mixture was evaporated in vacuo
2. additiondiluted with ethyl acetate
3. washwashed with saturated sodium hydrogen carbonate aqueous solution, brine
4. dry with materialdried over magnesium sulfate
5. customThe solvent was evaporated in vacuo
6. customtriturated from ethyl acetate