Acetone → HCID 178444015, 화합물

HRID 441336

반응식

HRID 441336 반응식
[Na].CC(C)=O.Cl.[C:7]([NH2:15])(=[NH:14])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].[Cl:16][C:17]1[CH:22]=[C:21]([CH3:23])[CH:20]=[CH:19][C:18]=1[N:24]=[C:25]=[S:26]>C1C=CC=CC=1.CCCCC>[Cl:16][C:17]1[CH:22]=[C:21]([CH3:23])[CH:20]=[CH:19][C:18]=1[NH:24][C:25]([NH:14][C:7](=[NH:15])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])=[S:26]

참가 물질

6

반응물 4

HCID 180Acetone2회HCID 1435292-Chloro-4-methylphenyl isothiocyanateHCID 5360545SodiumHCID 14144282Heptanimidamide hydrochloride

생성물 1

HCID 178444015HCID 178444015, 화합물

시약·촉매·용매 1

HCID 19707280Benzene n-pentane용매

실험 절차

Following a procedure similar to that described in Example 1 and using 2.3 g. sodium in 250 ml. dry acetone, 16.4 g. heptanamidine hydrochloride, and 16 g. 2-chloro-4-methylphenyl isothiocyanate (b.p. 80°-82° C./0.3 mm.; prepared from 2-chloro-4-methylaniline) in 100 ml. dry acetone there was obtained 1-(2-chloro-4-methylphenyl)-3-(heptanimidoyl)-2-thiourea, m.p. 78°-80° C. (from benzene-n-pentane); hydrochloride (23 g.), m.p. 138°-140° C. (from isopropyl alcohol).

출처 및 근거

ORD 기록
ord-79d54b055f0c443c9912ce0a682bb07b
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04039575

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