Phosphorus oxybromide → 2,5-Dibromo-3-methylpyrazine

HRID 441739노트

반응식

HRID 441739 반응식
O[C:2]1[C:7]([CH3:8])=[N:6][C:5]([Br:9])=[CH:4][N:3]=1.P(Br)(Br)([Br:12])=O>>[Br:12][C:2]1[C:7]([CH3:8])=[N:6][C:5]([Br:9])=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 24613Phosphorus oxybromideHCID 178432449HCID 178432449, 화합물

생성물 1

HCID 205289252,5-Dibromo-3-methylpyrazine

반응 조건

온도
175 °C

실험 절차

A mixture of 2-hydroxy-3-methyl-5-bromopyrazine and phosphorus oxybromide is heated at about 175° C. for several hours with constant stirring. After hydrolysis of the solution on ice the crude product is extracted with ether and distilled. The distillate is refluxed with phosphorus tribromide for several hours and, after cooling, the solution is hydrolyzed on ice and the product extracted with ether, the ether removed in vacuo to give 2,5-dibromo-3-methylpyrazine.

후처리

  1. extractionis extracted with ether
  2. distillationdistilled
  3. temperatureThe distillate is refluxed with phosphorus tribromide for several hours
  4. temperatureafter cooling
  5. extractionthe product extracted with ether
  6. customthe ether removed in vacuo

출처 및 근거

ORD 기록
ord-b9ab9e6526bc4d44a67587a462c9af2a
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04042586

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