Benzyl Alcohol → 2-Amino-3-morpholino-5-benzyloxypyrazine

HRID 441754

반응식

HRID 441754 반응식
[H-].[Na+].[CH2:3]([OH:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[NH2:11][C:12]1[C:17]([N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)=[N:16][C:15](Br)=[CH:14][N:13]=1>C1C=CC=CC=1>[NH2:11][C:12]1[C:17]([N:18]2[CH2:19][CH2:20][O:21][CH2:22][CH2:23]2)=[N:16][C:15]([O:10][CH2:3][C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)=[CH:14][N:13]=1

참가 물질

5

반응물 3

HCID 244Benzyl AlcoholHCID 24758Sodium hydrideHCID 167404415-Bromo-3-morpholinopyrazin-2-amine

생성물 1

HCID 205289342-Amino-3-morpholino-5-benzyloxypyrazine

시약·촉매·용매 1

HCID 241Benzene용매2회

실험 절차

Sodium hydride (0.1 mole) is added to benzyl alcohol (0.1 mole) in 100 ml. dry benzene and the mixture is refluxed one to two hours. The cooled solution is treated with 0.1 mole of 2-amino-3-morpholino-5-bromopyrazine in 100 ml. of benzene and the resulting mixture refluxed for 20-60 hours whereupon it is cooled, washed with water, dried and evaporated to give 2-amino-3-morpholino-5-benzyloxypyrazine.

후처리

  1. temperatureis cooled
  2. washwashed with water
  3. customdried
  4. customevaporated

출처 및 근거

ORD 기록
ord-a57c79a316fc4fe19a1677b8b9505dc3
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04042586

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