Dimethyl Sulfoxide → 2,3-Anthracenedicarbonitrile, 1,4-diamino-9,10-dihydro-9,10-dioxo-

HRID 441769

반응식

HRID 441769 반응식
[NH2:1][C:2]1[C:15]2[C:14](=[O:16])[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7](=[O:17])[C:6]=2[C:5]([NH2:18])=[CH:4][CH:3]=1.CS(C)=O.[C-:23]#[N:24].[Na+].[Cl-].[NH4+:27].[CH3:28]O>>[NH2:1][C:2]1[C:15]2[C:14](=[O:16])[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7](=[O:17])[C:6]=2[C:5]([NH2:18])=[C:4]([C:23]#[N:24])[C:3]=1[C:28]#[N:27]

참가 물질

6

반응물 5

HCID 679Dimethyl SulfoxideHCID 887MethanolHCID 8929Sodium CyanideHCID 25517Ammonium ChlorideHCID 31420Disperse Violet 1

생성물 1

HCID 664772,3-Anthracenedicarbonitrile, 1,4-diamino-9,10-dihydro-9,10-dioxo-

실험 절차

A suspension of 10 parts of 1,4-diaminoanthraquinone in 90 parts of dimethylsulfoxide is heated to 120° to 125° C., 12.5 parts of sodium cyanide is added all at once and then 5 parts of ammonium chloride is added within 15 minutes under an effective fume hood. The whole is stirred for another 3 hours at 120° to 125° C., whereupon one makes sure by a chromatogram that practically all of the starting material has been used up. The reaction mixture is allowed to cool and is diluted with 300 parts by volume of cold methanol, air is blown through under an effective fume hood for a short period, the precipitate is suction filtered and the filter cake is washed with methanol until the liquid running away is almost colorless. After drying, 9.5 parts of 1,4-diaminoanthraquinone-2,3-dinitrile is obtained.

후처리

  1. temperatureis heated to 120° to 125° C.
  2. additionis added within 15 minutes under an effective fume hood
  3. temperatureto cool
  4. waitis blown through under an effective fume hood for a short period
  5. filtrationfiltered
  6. washthe filter cake is washed with methanol until the liquid
  7. customAfter drying

출처 및 근거

ORD 기록
ord-860ac5cb959f4fe692b9aebd91aba7c5
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04042605

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