Benzyl Bromide → 2-Benzyl-6-methoxyisoquinolinium bromide
반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[N:8][CH:7]=[CH:6]2.[CH2:13]([Br:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CC(C)=O.CCOCC>[Br-:20].[CH2:13]([N+:8]1[CH:7]=[CH:6][C:5]2[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[CH:4]=2)[CH:9]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1참가 물질
5
실험 절차
6-Methoxyisoquinoline (1.6 g) and benzyl bromide (2 ml) in acetone (75 ml) were heated under reflux for 1 hour. The mixture was diluted with ether and cooled to 0°. The solid was filtered off and recrystallised from methanol/ether, and had m.p. 155°-158°.
후처리
- temperatureunder reflux for 1 hour
- temperaturecooled to 0°
- filtrationThe solid was filtered off
- customrecrystallised from methanol/ether
출처 및 근거
- ORD 기록
- ord-a515023c47354e99bfa7c2376c17c423
- 출처 데이터셋
- uspto-grants-1977_08
- 특허 번호
- US04042697
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