Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
P-Chloroacetophenone → 5-Chloro-3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | P-Chloroacetophenone | HCID 7467 | — |
| 반응물 | Phenylhydrazine | HCID 7516 | — |
| 반응물 | Diethyl Carbonate | HCID 7766 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Ethyl 3-(4-chlorophenyl)-3-oxopropanoate | HCID 101336 | — |
| 반응물 | 3-(4-Chlorophenyl)-1-phenyl-2-pyrazolin-5-one | HCID 10286088 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 5-Chloro-3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde | HCID 21418360 | — |
반응 단계
50.8 g of ethyl p-chlorobenzoylacetate (produced for example from p-chloroacetophenone, diethyl carbonate and sodium hydride with a yield of 72 %) 29 g of phenylhydrazine, 5 ml of glacial acetic acid and 150 ml of ethanol are heated in a nitrogen atmosphere for 1 hour at boiling point. After cooling in an ice bath 3-p-chlorophenyl-1-phenyl-2-pyrazoline-5-one is obtained with a yield of 84 %; F 160.5°-161.5°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04042702 |
| 출처 데이터셋 | uspto-grants-1977_08 |
| ORD ID | ord-d83de5859f6d48bcb6586b2b3b97c85c |
| 출처 메모 | uspto-grants-1977_08 |